In Democracy and the Claims of Nature, the leading thinkers in the fields of environmental, political, and social theory come together to discuss the tensions and sympathies of democratic ideals and environmental values. The prominent contributors reflect upon where we stand in our understanding of the relationship between democracy and the claims of nature. Democracy and the Claims of Nature bridges the gap between the often competing ideals of the two fields, leading to a greater understanding of each for the (...) other. (shrink)

Since Darwin, there has been a long and arduous struggle to understand the source and maintenance of natural genetic variation and its relationship to phenotype. The reason that this task is so difficult is that it requires integration of detailed, and as yet incomplete, knowledge from several biological disciplines, including evolutionary, population, and developmental genetics. In this ‘post‐genomic’ era, it is relatively easy to identify differences in the DNA sequence between individuals. However, the task remains to delineate how this abundant (...) genetic diversity actually contributes to phenotypic diversity. This necessitates tackling the problem of hidden genetic variation. Genetic polymorphisms can be conditionally cryptic, but have the potential to contribute to phenotypic variation in particular genetic backgrounds or under specific environmental conditions. A recent paper by Lauter and Doebley highlights the contribution of hidden genetic variation to traits characterizing the morphological evolution of modern maize from its wild grass‐like progenitor teosinte.1 This work is the first to demonstrate hidden variance for selected (agronomically ‘adaptive’) traits in a well‐characterized model for morphological evolution. BioEssays 24:685–689, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The rapid development of physics, the result of observations made and ideas introduced within the last few decades, has brought about a change in the whole system of physical concepts. This fact is common knowledge, and has already attracted the attention of philosophers. It is less well known that geometry too has had its crises, and undergone a reconstruction. For centuries, so-called “geometrical intuition” was used as a method of proof. In geometrical demonstrations, certain steps were allowed because they were (...) “self-evident,” because the correctness of the conclusion was “shown by the adjoined diagram,” etc. A crisis occurred in geometry because such intuition proved to be untrustworthy. Many of the propositions regarded as self-evident or based upon the consideration of diagrams turned out to be false. And so Euclidean geometry was reconstructed by methods free from all intuitive elements and strictly logical in nature. Moreover, for more than a century, various other geometries have been devised purely as logical constructions. Since they start with assumptions different from those of Euclid, and lead to conclusions partly in contradiction with his theorems, they are called “non-Euclidean.” Nevertheless, each one of these geometries is a closed system of propositions exempt from contradiction. Recently, some of them have even found application in physics. (shrink)

The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells (...) are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct‐3 and Brn‐2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation. (shrink)

According to J. G. Fichte, for a science to possess systematic form the science must begin with a first principle known with certainty and each proposition within the science must be validly connected to the first principle. The content of the Wissenschaftslehre consists of essentially one kind of content, what he calls “the acts of the human mind” He also holds that the Wissenschaftslehre provides each science its own first principle, thus making up part of its content. Following his first (...) publications, F. W. J. Schelling began to simultaneously develop a philosophy of nature, or Naturphilosophie, and to systematize his view of transcendental philosophy. His Ideas for a Philosophy of Nature and First Outline of a System of the Philosophy of Nature were followed by the System of Transcendental Idealism. Where Spinoza attempted to provide a model of the unconditional as a self‐causing substance, Schelling conceives of the unconditional as the absolute or self‐positing. (shrink)

In this brief note, we respond to Gottlieb and Lasser's critical commentary on our work on narrative research ethics. We argue that their concern for privileging voices needs to be balanced against the risk of exploiting some research participants, that conflicts of interest are best resolved through appropriately prioritizing ethical principles and in consultation with others, and that the researcher's ability to protect participants from harm can be enhanced through appropriate clinical training and access to clinical expertise. We welcome (...) Gottlieb and Lasser's specific recommendations for ethical practice in narrative research and encourage further ethical reflection by other researchers in this area. (shrink)

Die Wissenschaftslehre von 1812 - die letzte, die Fichte vollstandig vorgetragen hat - wird der Forschung erstmals in zuverlassiger Form vorgelegt. In ihr deduziert Fichte vom hochsten bestimmten 'Blick' aus, dem des sittlichen Wollens als einem der hoheren 'Schemata' der Erscheinung des Absoluten, die weiteren Momente des Wissens. Die Rechtslehre von 1812 wird ausschliesslich nach der Handschrift wiedergegeben. Drei nicht exakt zu datierende Texte zeigen Fichtes Reaktion auf die Zeitereignisse (u.a. Napoleons Kontributionsforderungen an den preussischen Staat). Ausserdem stellt der Philosoph (...) grundsatzliche Uberlegungen auch auf volkswirtschaftlichem Gebiet an (Bewertung landwirtschaftlicher Guter, Geldwerttheorie). The Wissenschaftslehre of 1812. This is the last complete version of Fichte's lectures on the Wissenschaftslehre, and it is here published for the first time in a reliable edition. This version begins with the most determinate "point of view," that of ethical willing, understood as one of the higher "schemata" of the absolute's appearance, from which Fichte deduces the additional moments of knowing. The texts of the 1812 Doctrine of Right [Rechtslehre] and the 1812 Doctrine of Ethics [Sittenlehre] published here are based entirely on the lecture manuscripts and incorporate nothing from previously published texts based upon other sources. -- Three additional texts, none of which can be precisely dated, illustrate Fichte's reaction to events of the day, such as Napoleon's demand for reparations from Prussia. Here the philosopher engages in fundamental reflections concerning the economic realm (the valuation of agricultural wealth, monetary theory). The introductory lecture of the Summer Semester of 1812 documents Fichte's efforts, at the start of the semester, to attract and to introduce as many interested students as possible to the study of philosophy. (shrink)

From the editor: On behalf of the editors of FPQ, I thank our colleagues for providing us their public addresses at the Celebration of Life of Professor Claudia Falconer Card of the University of Wisconsin-Madison, who died on Saturday, September 12, 2015. Claudia Card was the author of over one hundred articles and books, key works of moral and feminist philosophy including Confronting Evils: Terrorism, Torture, Genocide, The Atrocity Paradigm: A Theory of Evil, and The Unnatural Lottery: Character and Moral (...) Luck. She was the president of the Central division of the APA 2010-2011, which she often described as her favorite division of the APA. She earned her BA from UW-Madison, and her PhD in 1969 from Harvard University, as the advisee of John Rawls, whom she spoke of with affection as one of the most sensitive and generous of philosophers. I remain grateful to Claudia for being the sort of philosopher who helped her students, colleagues, and readers to confront our responsibilities, and the responsibilities of others, as she lived her own philosophy of taking responsibility for one’s own identity. K.J. Norlock. (shrink)

Johann Gottlieb Fichte hielt im Sommer 1805 in Erlangen öffentliche Vorlesungen zum Thema 'Über das Wesen des Gelehrten und seine Erscheinungen im Gebiete der Freiheit'. In diesen Vorlesungen erläuterte Fichte sein Verständnis des Wesens und der Aufgabe des Gelehrten und führte in seine Philosophie ein. Dieser Text ist ein wichtiges Zeugnis nicht nur für die Entwicklung von Fichtes Philosophie, sondern auch für die Geschichte des Deutschen Idealismus und das Verständnis von Bildung und Wissenschaft im frühen 19. Jahrhundert. Dieser Band (...) enthält den Text von J. G. Fichtes 'Über das Wesen des Gelehrten' (1805) zusammen mit Interpretationen, die Fichtes Vorlesungen im Rahmen seines eigenen Werkes und im Kontext der Philosophie- und Geistesgeschichte verorten. Mit Beiträgen von Paul Cobben, Alfred Denker, Elisabeth Kessler, C. Jeffery Kinlaw, Wilhelm Metz, Angelica Nuzzo, Ernst-Otto Onnasch, Tom Rockmore, Annette Sell, Michael Vater, Richard Velkley, Franziskus von Heereman, Holger Zaborowski u.a. (shrink)

English summary: Edition of Johann Gottlieb Fichte's (1762-1814) The Way Towards the Blessed Life. French text. French description: L'initiation a la vie bienheureuse presente la doctrine de la religion de J.G. Fichte. S'adressant a un grand public, ce cycle de conferences tenues a Berlin en 1806 et publiees la meme annee, n'est pas un traite theologique, mais il expose les principes d'une doctrine de la vie et de la beatitude qui constitue l'application pratique et religieuse de la doctrine de (...) la science. Chef d'oeuvre edifiant, ce texte qui eclaire remarquablement (autant qu'il les suppose) les ecrits theoriques de Fichte est livre ici dans une nouvelle traduction tenant compte des recherches recentes sur le philosophe, lesquelles connaissent un nouvel essor depuis quelques annees grace a l'edition, desormais achevee, de ses oeuvres Completes a l'Academie Bavaroise des Sciences. (shrink)

Über das Wesen des Gelehrten, und seine Erscheinungen im Gebiete der Freiheit (1805) von Johann Gottlieb Fichte -- Vorrede -- Erste Vorlesgun: Plan des Ganzen -- Zweite Vorlesung: Nähere Bestimmung des Begriffs der göttlichen Idee -- Dritte Vorlesung: Vom angehenden Gelehrten überhaupt; insbesondere vom Talente und Fleisse -- Vierte Vorlesung: Von der Rechtschaffenheit im Studiren -- Fünfte Vorlesung: Wie die Rechtschaffenheit des Studirenden sich äussere -- Sechste Vorlesung: Ueber die akademische Freiheit -- Siebente Vorlesung: Vom vollendeten Gelehrten im Allgemeinen (...) -- Achte Vorlesung: Vom Regenten -- Neunte Vorlesung: Vom mündlichen Gelehrte=Lehrer -- Zehnte Vorlesung: Vom Schriftsteller -- Menschliche Bildung und göttliche Idee. Über Struktur und Gedankengang von Fichtes Erlanger Vorlesungen Über das Wesen des Gelehrten / Annette Sell -- Über das Wesen des Gelehrten im Kontext der Wissenschaftslehre / C. Jeffery Kinlaw -- Fichte on Bestimmung and Wesen des Gelehrten / Angelica Nuzzo -- Fichte's Über das Wesen des Gelehrten, or the educated man as the salt of the Earth / Tom Rockmore -- Werkzeuge? Zur Herrschaft der Gelehrten im Kontext des Fichteschen Spätwerks / Franziskus von Heereman -- J.G. Fichtes Über das Wesen des Gelehrten und die Bestimmung des magister bei Thomas von Aquin / Wilhelm Metz -- Wie sich der Philosoph bei Descartes und Fichte zu sich selbst verhält / Elisabeth Kessler -- The ghosts of Kantian philosophy in Fichte's Über das Wesen des Gelehrten / Richard Velkley -- Reinhold über die Bildung eines neuen Menschen / Ernst-Otto Onnasch -- Die innerliche Verknüpfung von "objektiver Wissenschaft" und "subjektiver Bildung". Wilhelm von Humboldts Universitätsidee - mit einem Ausblick auf sein Kritik an Fichtes Überlegungen zum Gelehrten und zur Universität / Holger Zaborowski -- Die Todesangst als die Vermittlung zur absoluten Idee / Paul Cobben -- Fichte and Schelling / Michael Vater -- Fichtes Über das Wesen des Gelehrten und Heidegger / Alfred Denker. (shrink)

Josiah Royce relates the following story concerning the writing and publication of Johann Gottlieb Fichte's first major work, the Attempt at a Critique of All Revelation.Fichte … called upon Kant at Königsberg, in July, 1791. The aged, prudent, and … highly economical philosopher regarded this reverent, fiery, but obviously impecunious young disciple with a certain suspicion, and received his confidences coolly. The rebuff only heated Fichte the more. He tarried in Königsberg two months, in order … to write, for (...) presentation to Kant, a work on religious philosophy, which, once finished, proved to be so thoroughly in Kant's spirit that, when in the spring of the next year the book was published anonymously, it was very generally hailed by Kant's admirers as a new production of the master's own genius. Kant himself had to correct this misapprehension, and in doing so named, and now with warm praise, the real author. (shrink)

Anglophone philosophers have shown a surprising interest in Alexander Gottlieb Baumgarten’s aesthetics in recent years. At the same time, new approaches to aesthetics have been proposed that come very close to the original conception of aesthetics that Baumgarten introduced in the middle of the eighteenth century. In light of these developments, this article undertakes a critical examination of a central concept in Baumgarten’s poetics and aesthetics—extensive clarity. It argues that historians of philosophy and contemporary aestheticians should be wary of (...) this concept for two reasons. First, in Baumgarten’s poetics, the extensive clarity of sensible representations constitutes a dubious standard with which to determine whether those representations are “poetic.” Second, in aesthetics, using extensive clarity as an alternative standard with which to determine the perfection of sensible cognition undermines the “marriage of reason and experience” that characterized the Leibnizian-Wolffian philosophy and raises the specter of dualism that Kant tried, with questionable success, to address in the ‘Schematism’ chapter of the Critique of Pure Reason. The article concludes that historians of philosophy should acknowledge the philosophical shortcomings of Baumgarten’s conception of extensive clarity and contemporary aesthetics should not reproduce them. (shrink)

L'accusation d'atheisme, qui couta a Fichte sa chaire a l'Universite d'Iena et compromit gravement, et pour longtemps, la reputation de sa doctrine, concentre tous les anathemes par lesquels l'esprit de calomnie pouvait tenter, avec un certain succes, d'empecher une pensee trop libre d'agir sur son siecle en forgeant une image plus forte et plus courageuse de l'avenir du monde. Au mepris de toute contradiction, les accusateurs firent suspecter la philosophie transcendantale de conduire, a travers le developpement pratique qu'en donnait la (...) Doctrine de la science, autant au scepticisme en matiere de religion qu'au pantheisme, autant a l'anarchisme qu'a l'autoritarisme revolutionnaire. On trouvera dans le present volume la traduction des articles par lesquels Fichte se defendit publiquement contre cette accusation, ainsi que l'ensemble des textes qu'il consacra a la question religieuse depuis la fin de ses etudes de theologie jusqu'au declenchement de la Querelle de l'atheisme. (shrink)

We prove linear and polynomial growth properties of sets and functions that are existentially definable in the ordered group of integers with divisibility. We determine the laws of addition with order and divisibility.

Regulated secretory proteins are stored within specialized vesicles known as secretory granules. It is not known how proteins are sorted into these organelles. Regulated proteins may possess targeting signals which interact with specific sorting receptors in the lumen of the trans‐Golgi network (TGN) prior to their aggregation to form the characteristic dense‐core of the granule. Alternatively, sorting may occur as the result of specific aggregation of regulated proteins in the TGN. Aggregates may be directed to secretory granules by interaction of (...) a targeting signal on the surface with a sorting receptor. Novel targeting signals which confer on regulated proteins a tendency to aggregate under certain conditions, and in so doing cause them to be incorporated into secretory granules, have been implicated. Specific targeting signals may also play a role in directing membrane proteins to secretory granules. (shrink)

ALTHOUGH the content of Alexander Gottlieb Baumgarten's Aesthetica seems to be familiar in German philosophical circles, it is relatively unknown outside Germany. Most of us are aware that it was Baumgarten who coined the name "aesthetics" for the new philosophical discipline his Aesthetica was intended to establish; but as for the content of that work, our acquaintance is likely to be indirect, through two remarks of Kant. Explaining his own use of "Transcendental Aesthetic" in the Critique of Pure Reason, (...) Kant criticizes Baumgarten's "abortive attempt... to bring the critical treatment of the beautiful under rational principles and so to raise its rules to the rank of a science". In the Critique of Judgment, it is generally assumed to be Baumgarten Kant has in mind when, arguing that judgments of beauty are not cognitive or "logical" judgments, he criticizes the view that beauty is perfection known confusedly or indistinctly. Combining Kant's remark with Leibniz's view that beauty is--or, more precisely, flows from--perfection, we might conclude that Baumgarten simply lowered beauty from the level of distinct to that of confused concepts and tried to deduce its rules from the concept of perfection. If this was indeed Baumgarten's project, we might well ask to be excused from pursuing the subject further. (shrink)

This exploratory study assessed the use of functional Near Infrared Spectroscopy (fNIRS) to examine hemodynamic response patterns during sentence processing. Four groups of participants: monolingual English children, bilingual Chinese-English children, bilingual Chinese-English adults and monolingual English adults were given an agent selection syntactic processing task. Bilingual child participants were classified as simultaneous or sequential bilinguals to examine the impact of first language, age of second-language acquisition (AoL2A), and the length of second language experience on behavioral performance and cortical activation. Participants (...) were asked to select the agent of four types of sentences: subject-verb-object (SVO), passive (PAS), subject-extracted relative clause (SR), and object-extracted relative clause (OR) adopted from the “Whatdunit” task by Montgomery et al. (2016). Semantic cues were removed by using inanimate nouns for agents and patients, which constrained participants to make decisions based on syntactic knowledge. Behavioral results showed greater accuracy for canonical SVO and SR sentence types than for noncanonical OR and PAS sentence types, which aligns with prior studies. Neuroimaging results revealed greater hemodynamic responses to relative clauses (i.e., SR and OR sentences) than to simple sentences (SVO and PAS), especially for Chinese-English bilinguals suggesting first-language transfer influencing sentence processing in English. The effects AoL2A and the length of second language experience showed no significant differences between simultaneous and sequential bilinguals or between bilingual adults and children for identifying the correct agent in each sentence. However, neuroimaging results demonstrated greater hemodynamic responses in right dorsolateral prefrontal cortex (DLPFC) and left inferior parietal lobule (IPL) in simultaneous bilinguals compared to sequential bilinguals and greater hemodynamic responses in left and right DLPFC and left IPL among bilingual adults. Different behavioral and neural hemodynamic response patterns afford new insights into the effects of syntactic knowledge on sentence processing. (shrink)